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Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics
RB1 mutational inactivation is a cancer driver in various types of cancer including lung cancer, making it an important target for therapeutic exploitation. We performed chemical and genetic vulnerability screens in RB1-isogenic lung cancer pair and herein report that aurora kinase A (AURKA) inhibit...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Nat Commun |
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| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Nature Publishing Group UK
2020
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7547687/ https://ncbi.nlm.nih.gov/pubmed/33037191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18872-0 |
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