Histone Acetyltransferase (HAT) P300/CBP Inhibitors Induce Synthetic Lethality in PTEN-Deficient Colorectal Cancer Cells through Destabilizing AKT

PTEN, a tumor suppressor, is found loss of function in many cancers, including colorectal cancer. To identify the synthetic lethal compounds working with PTEN deficiency, we performed a synthetic lethality drug screening with PTEN-isogenic colorectal cancer cells. From the screening, we found that P...

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Detalhes bibliográficos
Publicado no:Int J Biol Sci
Main Authors: Liu, Yifan, Yang, Eun Ju, Shi, Changxiang, Mou, Pui Kei, Zhang, Baoyuan, Wu, Changjie, Lyu, Junfang, Shim, Joong Sup
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7211175/
https://ncbi.nlm.nih.gov/pubmed/32398948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.42197
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