Reactive fibrosis precedes doxorubicin‐induced heart failure through sterile inflammation

AIMS: Doxorubicin (DOX)‐induced heart failure has a poor prognosis, and effective treatments have not been established. Because DOX shows cumulative cardiotoxicity, we hypothesized that minimal cardiac remodelling occurred at the initial stage in activating cardiac fibroblasts. Our aim was to invest...

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Dettagli Bibliografici
Pubblicato in:ESC Heart Fail
Autori principali: Tanaka, Ryo, Umemura, Masanari, Narikawa, Masatoshi, Hikichi, Mayu, Osaw, Kohei, Fujita, Takayuki, Yokoyama, Utako, Ishigami, Tomoaki, Tamura, Kouichi, Ishikawa, Yoshihiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Original Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160475/
https://ncbi.nlm.nih.gov/pubmed/31984667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ehf2.12616
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