Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways

Although doxorubicin (DOX)-induced cardiomyopathy causes lethal heart failure (HF), no early detection or effective treatment methods are available. The principal mechanisms of cardiotoxicity are considered to involve oxidative stress and apoptosis of cardiomyocytes. However, the effect of DOX on ca...

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Veröffentlicht in:PLoS One
Hauptverfasser: Narikawa, Masatoshi, Umemura, Masanari, Tanaka, Ryo, Hikichi, Mayu, Nagasako, Akane, Fujita, Takayuki, Yokoyama, Utako, Ishigami, Tomoaki, Kimura, Kazuo, Tamura, Kouichi, Ishikawa, Yoshihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6742217/
https://ncbi.nlm.nih.gov/pubmed/31513610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0221940
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