Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways

Although doxorubicin (DOX)-induced cardiomyopathy causes lethal heart failure (HF), no early detection or effective treatment methods are available. The principal mechanisms of cardiotoxicity are considered to involve oxidative stress and apoptosis of cardiomyocytes. However, the effect of DOX on ca...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Narikawa, Masatoshi, Umemura, Masanari, Tanaka, Ryo, Hikichi, Mayu, Nagasako, Akane, Fujita, Takayuki, Yokoyama, Utako, Ishigami, Tomoaki, Kimura, Kazuo, Tamura, Kouichi, Ishikawa, Yoshihiro
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6742217/
https://ncbi.nlm.nih.gov/pubmed/31513610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0221940
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