Reactive fibrosis precedes doxorubicin‐induced heart failure through sterile inflammation

AIMS: Doxorubicin (DOX)‐induced heart failure has a poor prognosis, and effective treatments have not been established. Because DOX shows cumulative cardiotoxicity, we hypothesized that minimal cardiac remodelling occurred at the initial stage in activating cardiac fibroblasts. Our aim was to invest...

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Detalhes bibliográficos
Publicado no:ESC Heart Fail
Main Authors: Tanaka, Ryo, Umemura, Masanari, Narikawa, Masatoshi, Hikichi, Mayu, Osaw, Kohei, Fujita, Takayuki, Yokoyama, Utako, Ishigami, Tomoaki, Tamura, Kouichi, Ishikawa, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160475/
https://ncbi.nlm.nih.gov/pubmed/31984667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ehf2.12616
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