Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation

Systemic inflammation can lead to coagulopathy and disseminated intravascular coagulation (DIC). In prior studies, the recombinant A2 domain of human von Willebrand factor (VWF; A2 protein) attenuated DIC and decreased mortality in lipopolysaccharide (LPS)-treated mice. Here, we performed studies to...

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Bibliographic Details
Published in:Blood Adv
Main Authors: Valladolid, Christian, Martinez-Vargas, Marina, Sekhar, Nitin, Lam, Fong, Brown, Cameron, Palzkill, Timothy, Tischer, Alexander, Auton, Mathew, Vijayan, K. Vinod, Rumbaut, Rolando E., Nguyen, Trung C., Cruz, Miguel A.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2020
Subjects:
Thrombosis and Hemostasis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160269/
https://ncbi.nlm.nih.gov/pubmed/32259201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001500
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