Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation

Systemic inflammation can lead to coagulopathy and disseminated intravascular coagulation (DIC). In prior studies, the recombinant A2 domain of human von Willebrand factor (VWF; A2 protein) attenuated DIC and decreased mortality in lipopolysaccharide (LPS)-treated mice. Here, we performed studies to...

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Dades bibliogràfiques
Publicat a:Blood Adv
Autors principals: Valladolid, Christian, Martinez-Vargas, Marina, Sekhar, Nitin, Lam, Fong, Brown, Cameron, Palzkill, Timothy, Tischer, Alexander, Auton, Mathew, Vijayan, K. Vinod, Rumbaut, Rolando E., Nguyen, Trung C., Cruz, Miguel A.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2020
Matèries:
Thrombosis and Hemostasis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160269/
https://ncbi.nlm.nih.gov/pubmed/32259201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001500
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