Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice

To explore the contribution of Vav1, a hematopoietic signal transducer, to pancreatic ductal adenocarcinoma (PDAC) development, we generated transgenic mouse lines expressing, Vav1, K-Ras(G12D), or both K-Ras(G12D) and Vav1 in pancreatic acinar cells. Co-expression of Vav1 and K-Ras(G12D) synergisti...

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Bibliografiske detaljer
Udgivet i:Life Sci Alliance
Main Authors: Salaymeh, Yaser, Farago, Marganit, Sebban, Shulamit, Shalom, Batel, Pikarsky, Eli, Katzav, Shulamit
Format: Artigo
Sprog:Inglês
Udgivet: Life Science Alliance LLC 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156281/
https://ncbi.nlm.nih.gov/pubmed/32277014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000661
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