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Tyrosine Residues at the Carboxyl Terminus of Vav1 Play an Important Role in Regulation of Its Biological Activity

The guanine nucleotide exchange factor (GEF) Vav1 is an essential signal transducer protein in the hematopoietic system, where it is expressed physiologically. It is also involved in several human malignancies. Tyrosine phosphorylation at the Vav1 amino terminus plays a central role in regulating it...

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מידע ביבליוגרפי
Main Authors: Lazer, Galit, Pe'er, Liron, Farago, Marganit, Machida, Kazuya, Mayer, Bruce J., Katzav, Shulamit
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906301/
https://ncbi.nlm.nih.gov/pubmed/20457609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.094508
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