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Vav1 mutations identified in human cancers give rise to different oncogenic phenotypes

Vav1 is physiologically active as a GDP/GTP nucleotide exchange factor (GEF) in the hematopoietic system. Overexpression of Vav1 in multiple tumor types is known to enhance oncogenicity, yet whether or not Vav1 is a bona fide oncogene is still a matter of debate. Although mutations in Vav1 were rece...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncogenesis
Asıl Yazarlar: Shalom, Batel, Farago, Marganit, Pikarsky, Eli, Katzav, Shulamit
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175932/
https://ncbi.nlm.nih.gov/pubmed/30297765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-018-0091-1
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