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Vav1 mutations identified in human cancers give rise to different oncogenic phenotypes
Vav1 is physiologically active as a GDP/GTP nucleotide exchange factor (GEF) in the hematopoietic system. Overexpression of Vav1 in multiple tumor types is known to enhance oncogenicity, yet whether or not Vav1 is a bona fide oncogene is still a matter of debate. Although mutations in Vav1 were rece...
Shranjeno v:
| izdano v: | Oncogenesis |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6175932/ https://ncbi.nlm.nih.gov/pubmed/30297765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-018-0091-1 |
| Oznake: |
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