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Mechanism of protein cleavage at asparagine leading to protein-protein crosslinks

Long-lived proteins are present in numerous tissues within the human body. With age, they deteriorate, often leading to the formation of irreversible modifications such as peptide bond cleavage and covalent crosslinking. Currently understanding of the mechanism of formation of these crosslinks is li...

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Pubblicato in:Biochem J
Autori principali: Friedrich, Michael G., Wang, Zhen, Schey, Kevin L., Truscott, Roger J. W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156126/
https://ncbi.nlm.nih.gov/pubmed/31794011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190743
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