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Spontaneous cross-linking of proteins at aspartate and asparagine residues is mediated via a succinimide intermediate

The breakdown of long-lived proteins is associated with aging, as well as disease, however our understanding of the molecular processes involved is still limited. Of particular relevance, crosslinked proteins are often reported in aged tissues but the mechanisms for their formation are poorly unders...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Friedrich, Michael G., Wang, Zhen, Schey, Kevin L., Truscott, Roger J. W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7029958/
https://ncbi.nlm.nih.gov/pubmed/30181147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20180529
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