Structural Insight into IAPP‐Derived Amyloid Inhibitors and Their Mechanism of Action

Designed peptides derived from the islet amyloid polypeptide (IAPP) cross‐amyloid interaction surface with Aβ (termed interaction surface mimics or ISMs) have been shown to be highly potent inhibitors of Aβ amyloid self‐assembly. However, the molecular mechanism of their function is not well underst...

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Bibliografiske detaljer
Udgivet i:Angew Chem Int Ed Engl
Main Authors: Niu, Zheng, Prade, Elke, Malideli, Eleni, Hille, Kathleen, Jussupow, Alexander, Mideksa, Yonatan G., Yan, Li‐Mei, Qian, Chen, Fleisch, Markus, Messias, Ana C., Sarkar, Riddhiman, Sattler, Michael, Lamb, Don C., Feige, Matthias J., Camilloni, Carlo, Kapurniotu, Aphrodite, Reif, Bernd
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7154662/
https://ncbi.nlm.nih.gov/pubmed/31863711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201914559
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