The Human Host‐Defense Peptide Cathelicidin LL‐37 is a Nanomolar Inhibitor of Amyloid Self‐Assembly of Islet Amyloid Polypeptide (IAPP)

Amyloid self‐assembly of islet amyloid polypeptide (IAPP) is linked to pancreatic inflammation, β‐cell degeneration, and the pathogenesis of type 2 diabetes (T2D). The multifunctional host‐defence peptides (HDPs) cathelicidins play crucial roles in inflammation. Here, we show that the antimicrobial...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Angew Chem Int Ed Engl
Main Authors: Armiento, Valentina, Hille, Kathleen, Naltsas, Denise, Lin, Jennifer S., Barron, Annelise E., Kapurniotu, Aphrodite
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7497016/
https://ncbi.nlm.nih.gov/pubmed/31999880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202000148
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