Structural Insight into IAPP‐Derived Amyloid Inhibitors and Their Mechanism of Action

Designed peptides derived from the islet amyloid polypeptide (IAPP) cross‐amyloid interaction surface with Aβ (termed interaction surface mimics or ISMs) have been shown to be highly potent inhibitors of Aβ amyloid self‐assembly. However, the molecular mechanism of their function is not well underst...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Principais autores: Niu, Zheng, Prade, Elke, Malideli, Eleni, Hille, Kathleen, Jussupow, Alexander, Mideksa, Yonatan G., Yan, Li‐Mei, Qian, Chen, Fleisch, Markus, Messias, Ana C., Sarkar, Riddhiman, Sattler, Michael, Lamb, Don C., Feige, Matthias J., Camilloni, Carlo, Kapurniotu, Aphrodite, Reif, Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7154662/
https://ncbi.nlm.nih.gov/pubmed/31863711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201914559
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