Mechanistic basis and efficacy of targeting the β-catenin–TCF7L2–JMJD6–c-Myc axis to overcome resistance to BET inhibitors

The promising activity of BET protein inhibitors (BETi’s) is compromised by adaptive or innate resistance in acute myeloid leukemia (AML). Here, modeling of BETi-persister/resistance (BETi-P/R) in human postmyeloproliferative neoplasm (post-MPN) secondary AML (sAML) cells demonstrated accessible and...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Blood
मुख्य लेखकों: Saenz, Dyana T., Fiskus, Warren, Mill, Christopher P., Perera, Dimuthu, Manshouri, Taghi, Lara, Bernardo H., Karkhanis, Vrajesh, Sharma, Sunil, Horrigan, Stephen K., Bose, Prithviraj, Kadia, Tapan M., Masarova, Lucia, DiNardo, Courtney D., Borthakur, Gautam, Khoury, Joseph D., Takahashi, Koichi, Bhaskara, Srividya, Lin, Charles Y., Green, Michael R., Coarfa, Cristian, Crews, Craig M., Verstovsek, Srdan, Bhalla, Kapil N.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society of Hematology 2020
विषय:
Myeloid Neoplasia
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7146021/
https://ncbi.nlm.nih.gov/pubmed/32068780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002922
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