Mechanistic basis and efficacy of targeting the β-catenin–TCF7L2–JMJD6–c-Myc axis to overcome resistance to BET inhibitors

The promising activity of BET protein inhibitors (BETi’s) is compromised by adaptive or innate resistance in acute myeloid leukemia (AML). Here, modeling of BETi-persister/resistance (BETi-P/R) in human postmyeloproliferative neoplasm (post-MPN) secondary AML (sAML) cells demonstrated accessible and...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Saenz, Dyana T., Fiskus, Warren, Mill, Christopher P., Perera, Dimuthu, Manshouri, Taghi, Lara, Bernardo H., Karkhanis, Vrajesh, Sharma, Sunil, Horrigan, Stephen K., Bose, Prithviraj, Kadia, Tapan M., Masarova, Lucia, DiNardo, Courtney D., Borthakur, Gautam, Khoury, Joseph D., Takahashi, Koichi, Bhaskara, Srividya, Lin, Charles Y., Green, Michael R., Coarfa, Cristian, Crews, Craig M., Verstovsek, Srdan, Bhalla, Kapil N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7146021/
https://ncbi.nlm.nih.gov/pubmed/32068780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002922
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