Mechanistic basis and efficacy of targeting the β-catenin–TCF7L2–JMJD6–c-Myc axis to overcome resistance to BET inhibitors

The promising activity of BET protein inhibitors (BETi’s) is compromised by adaptive or innate resistance in acute myeloid leukemia (AML). Here, modeling of BETi-persister/resistance (BETi-P/R) in human postmyeloproliferative neoplasm (post-MPN) secondary AML (sAML) cells demonstrated accessible and...

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Veröffentlicht in:Blood
Hauptverfasser: Saenz, Dyana T., Fiskus, Warren, Mill, Christopher P., Perera, Dimuthu, Manshouri, Taghi, Lara, Bernardo H., Karkhanis, Vrajesh, Sharma, Sunil, Horrigan, Stephen K., Bose, Prithviraj, Kadia, Tapan M., Masarova, Lucia, DiNardo, Courtney D., Borthakur, Gautam, Khoury, Joseph D., Takahashi, Koichi, Bhaskara, Srividya, Lin, Charles Y., Green, Michael R., Coarfa, Cristian, Crews, Craig M., Verstovsek, Srdan, Bhalla, Kapil N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2020
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7146021/
https://ncbi.nlm.nih.gov/pubmed/32068780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002922
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