Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio

The accumulation of mutations is frequently associated with alterations in gene function leading to the onset of diseases, including cancer. Aiming to find novel genes that contribute to the stability of the genome, we screened the Saccharomyces cerevisiae deletion collection for increased mutator p...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Schmidt, Tobias T, Sharma, Sushma, Reyes, Gloria X, Kolodziejczak, Anna, Wagner, Tina, Luke, Brian, Hofer, Anders, Chabes, Andrei, Hombauer, Hans
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145683/
https://ncbi.nlm.nih.gov/pubmed/31647103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1006
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