Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio

The accumulation of mutations is frequently associated with alterations in gene function leading to the onset of diseases, including cancer. Aiming to find novel genes that contribute to the stability of the genome, we screened the Saccharomyces cerevisiae deletion collection for increased mutator p...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Schmidt, Tobias T, Sharma, Sushma, Reyes, Gloria X, Kolodziejczak, Anna, Wagner, Tina, Luke, Brian, Hofer, Anders, Chabes, Andrei, Hombauer, Hans
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145683/
https://ncbi.nlm.nih.gov/pubmed/31647103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1006
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