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DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools

To maintain dNTP pool homeostasis and preserve genetic integrity of nuclear and mitochondrial genomes, the synthesis and degradation of DNA precursors must be precisely regulated. Human all-alpha dCTP pyrophosphatase 1 (DCTPP1) is a dNTP pyrophosphatase with high affinity for dCTP and 5′-modified dC...

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Bibliografske podrobnosti
izdano v:Cell Mol Life Sci
Main Authors: Martínez-Arribas, Blanca, Requena, Cristina E., Pérez-Moreno, Guiomar, Ruíz-Pérez, Luis M., Vidal, Antonio E., González-Pacanowska, Dolores
Format: Artigo
Jezik:Inglês
Izdano: Springer International Publishing 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162842/
https://ncbi.nlm.nih.gov/pubmed/31377845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-019-03250-x
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