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DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools

To maintain dNTP pool homeostasis and preserve genetic integrity of nuclear and mitochondrial genomes, the synthesis and degradation of DNA precursors must be precisely regulated. Human all-alpha dCTP pyrophosphatase 1 (DCTPP1) is a dNTP pyrophosphatase with high affinity for dCTP and 5′-modified dC...

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Bibliografiska uppgifter
I publikationen:Cell Mol Life Sci
Huvudupphovsmän: Martínez-Arribas, Blanca, Requena, Cristina E., Pérez-Moreno, Guiomar, Ruíz-Pérez, Luis M., Vidal, Antonio E., González-Pacanowska, Dolores
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer International Publishing 2019
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162842/
https://ncbi.nlm.nih.gov/pubmed/31377845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-019-03250-x
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