DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools

To maintain dNTP pool homeostasis and preserve genetic integrity of nuclear and mitochondrial genomes, the synthesis and degradation of DNA precursors must be precisely regulated. Human all-alpha dCTP pyrophosphatase 1 (DCTPP1) is a dNTP pyrophosphatase with high affinity for dCTP and 5′-modified dC...

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Bibliographic Details
Published in:Cell Mol Life Sci
Main Authors: Martínez-Arribas, Blanca, Requena, Cristina E., Pérez-Moreno, Guiomar, Ruíz-Pérez, Luis M., Vidal, Antonio E., González-Pacanowska, Dolores
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2019
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162842/
https://ncbi.nlm.nih.gov/pubmed/31377845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-019-03250-x
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