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DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools
To maintain dNTP pool homeostasis and preserve genetic integrity of nuclear and mitochondrial genomes, the synthesis and degradation of DNA precursors must be precisely regulated. Human all-alpha dCTP pyrophosphatase 1 (DCTPP1) is a dNTP pyrophosphatase with high affinity for dCTP and 5′-modified dC...
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| Publicado no: | Cell Mol Life Sci |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7162842/ https://ncbi.nlm.nih.gov/pubmed/31377845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-019-03250-x |
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