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DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools
To maintain dNTP pool homeostasis and preserve genetic integrity of nuclear and mitochondrial genomes, the synthesis and degradation of DNA precursors must be precisely regulated. Human all-alpha dCTP pyrophosphatase 1 (DCTPP1) is a dNTP pyrophosphatase with high affinity for dCTP and 5′-modified dC...
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| Publicat a: | Cell Mol Life Sci |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Springer International Publishing
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7162842/ https://ncbi.nlm.nih.gov/pubmed/31377845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-019-03250-x |
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