Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio

The accumulation of mutations is frequently associated with alterations in gene function leading to the onset of diseases, including cancer. Aiming to find novel genes that contribute to the stability of the genome, we screened the Saccharomyces cerevisiae deletion collection for increased mutator p...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Schmidt, Tobias T, Sharma, Sushma, Reyes, Gloria X, Kolodziejczak, Anna, Wagner, Tina, Luke, Brian, Hofer, Anders, Chabes, Andrei, Hombauer, Hans
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2020
Gaiak:
Genome Integrity, Repair and Replication
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145683/
https://ncbi.nlm.nih.gov/pubmed/31647103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1006
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