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Incorporation of dUTP does not mediate mutation of A:T base pairs in Ig genes in vivo
Activation-induced cytidine deaminase (AID) protein initiates Ig gene mutation by deaminating cytosines, converting them into uracils. Excision of AID-induced uracils by uracil-N-glycosylase is responsible for most transversion mutations at G:C base pairs. On the other hand, processing of AID-induce...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3001060/ https://ncbi.nlm.nih.gov/pubmed/20705648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq682 |
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