Incorporation of dUTP does not mediate mutation of A:T base pairs in Ig genes in vivo

Activation-induced cytidine deaminase (AID) protein initiates Ig gene mutation by deaminating cytosines, converting them into uracils. Excision of AID-induced uracils by uracil-N-glycosylase is responsible for most transversion mutations at G:C base pairs. On the other hand, processing of AID-induce...

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Detalhes bibliográficos
Main Authors: Sharbeen, George, Cook, Adam J. L., Lau, K. K. Edwin, Raftery, Joanna, Yee, Christine W. Y., Jolly, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001060/
https://ncbi.nlm.nih.gov/pubmed/20705648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq682
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