Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio

The accumulation of mutations is frequently associated with alterations in gene function leading to the onset of diseases, including cancer. Aiming to find novel genes that contribute to the stability of the genome, we screened the Saccharomyces cerevisiae deletion collection for increased mutator p...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Schmidt, Tobias T, Sharma, Sushma, Reyes, Gloria X, Kolodziejczak, Anna, Wagner, Tina, Luke, Brian, Hofer, Anders, Chabes, Andrei, Hombauer, Hans
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2020
Onderwerpen:
Genome Integrity, Repair and Replication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145683/
https://ncbi.nlm.nih.gov/pubmed/31647103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1006
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