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Dynamical model of the CLC-2 ion channel reveals conformational changes associated with selectivity-filter gating
This work reports a dynamical Markov state model of CLC-2 “fast” (pore) gating, based on 600 microseconds of molecular dynamics (MD) simulation. In the starting conformation of our CLC-2 model, both outer and inner channel gates are closed. The first conformational change in our dataset involves rot...
Tallennettuna:
| Julkaisussa: | PLoS Comput Biol |
|---|---|
| Päätekijät: | , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Public Library of Science
2020
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7145265/ https://ncbi.nlm.nih.gov/pubmed/32226009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007530 |
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