Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel

CLC-2 is a voltage-gated chloride channel that is widely expressed in mammalian tissues. In the central nervous system, CLC-2 appears in neurons and glia. Studies to define how this channel contributes to normal and pathophysiological function in the central nervous system raise questions that remai...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Koster, Anna K., Reese, Austin L., Kuryshev, Yuri, Wen, Xianlan, McKiernan, Keri A., Gray, Erin E., Wu, Caiyun, Huguenard, John R., Maduke, Merritt, Du Bois, J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7768775/
https://ncbi.nlm.nih.gov/pubmed/33277431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009977117
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