A selective class of inhibitors for the CLC-Ka chloride ion channel

CLC proteins are a ubiquitously expressed family of chloride-selective ion channels and transporters. A dearth of pharmacological tools for modulating CLC gating and ion conduction limits investigations aimed at understanding CLC structure/function and physiology. Herein, we describe the design, syn...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Koster, Anna K., Wood, Chase A. P., Thomas-Tran, Rhiannon, Chavan, Tanmay S., Almqvist, Jonas, Choi, Kee-Hyun, Du Bois, J., Maduke, Merritt
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003504/
https://ncbi.nlm.nih.gov/pubmed/29669921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720584115
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