Wird geladen...
Dynamical model of the CLC-2 ion channel reveals conformational changes associated with selectivity-filter gating
This work reports a dynamical Markov state model of CLC-2 “fast” (pore) gating, based on 600 microseconds of molecular dynamics (MD) simulation. In the starting conformation of our CLC-2 model, both outer and inner channel gates are closed. The first conformational change in our dataset involves rot...
Gespeichert in:
| Veröffentlicht in: | PLoS Comput Biol |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2020
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7145265/ https://ncbi.nlm.nih.gov/pubmed/32226009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007530 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|