Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes

Reverse transcription (RT) of RNA templates containing RNA modifications leads to synthesis of cDNA containing information on the modification in the form of misincorporation, arrest, or nucleotide skipping events. A compilation of such events from multiple cDNAs represents an RT-signature that is t...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Werner, Stephan, Schmidt, Lukas, Marchand, Virginie, Kemmer, Thomas, Falschlunger, Christoph, Sednev, Maksim V, Bec, Guillaume, Ennifar, Eric, Höbartner, Claudia, Micura, Ronald, Motorin, Yuri, Hildebrandt, Andreas, Helm, Mark
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Molecular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144921/
https://ncbi.nlm.nih.gov/pubmed/32095818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa113
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