Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes

Reverse transcription (RT) of RNA templates containing RNA modifications leads to synthesis of cDNA containing information on the modification in the form of misincorporation, arrest, or nucleotide skipping events. A compilation of such events from multiple cDNAs represents an RT-signature that is t...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Werner, Stephan, Schmidt, Lukas, Marchand, Virginie, Kemmer, Thomas, Falschlunger, Christoph, Sednev, Maksim V, Bec, Guillaume, Ennifar, Eric, Höbartner, Claudia, Micura, Ronald, Motorin, Yuri, Hildebrandt, Andreas, Helm, Mark
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2020
Ämnen:
Molecular Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144921/
https://ncbi.nlm.nih.gov/pubmed/32095818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa113
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