Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes

Reverse transcription (RT) of RNA templates containing RNA modifications leads to synthesis of cDNA containing information on the modification in the form of misincorporation, arrest, or nucleotide skipping events. A compilation of such events from multiple cDNAs represents an RT-signature that is t...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Werner, Stephan, Schmidt, Lukas, Marchand, Virginie, Kemmer, Thomas, Falschlunger, Christoph, Sednev, Maksim V, Bec, Guillaume, Ennifar, Eric, Höbartner, Claudia, Micura, Ronald, Motorin, Yuri, Hildebrandt, Andreas, Helm, Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Molecular Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144921/
https://ncbi.nlm.nih.gov/pubmed/32095818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa113
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