Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes

Reverse transcription (RT) of RNA templates containing RNA modifications leads to synthesis of cDNA containing information on the modification in the form of misincorporation, arrest, or nucleotide skipping events. A compilation of such events from multiple cDNAs represents an RT-signature that is t...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Werner, Stephan, Schmidt, Lukas, Marchand, Virginie, Kemmer, Thomas, Falschlunger, Christoph, Sednev, Maksim V, Bec, Guillaume, Ennifar, Eric, Höbartner, Claudia, Micura, Ronald, Motorin, Yuri, Hildebrandt, Andreas, Helm, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144921/
https://ncbi.nlm.nih.gov/pubmed/32095818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa113
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