Absence of MeCP2 binding to non-methylated GT-rich sequences in vivo

MeCP2 is a nuclear protein that binds to sites of cytosine methylation in the genome. While most evidence confirms this epigenetic mark as the primary determinant of DNA binding, MeCP2 is also reported to have an affinity for non-methylated DNA sequences. Here we investigated the molecular basis and...

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Udgivet i:Nucleic Acids Res
Main Authors: Connelly, John C, Cholewa-Waclaw, Justyna, Webb, Shaun, Steccanella, Verdiana, Waclaw, Bartlomiej, Bird, Adrian
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Gene regulation, Chromatin and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144902/
https://ncbi.nlm.nih.gov/pubmed/32064528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa102
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