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Lysosomal degradation of depolarized mitochondria is rate-limiting in OPTN-dependent neuronal mitophagy
Damaged mitochondria are selectively removed from the cell in a process termed mitophagy. This mitochondrial quality control mechanism is important for neuronal homeostasis, and mutations in pathway components are causative for Parkinson disease and amyotrophic lateral sclerosis (ALS). Here, we disc...
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| Udgivet i: | Autophagy |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7144876/ https://ncbi.nlm.nih.gov/pubmed/32131674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2020.1734330 |
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