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Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons
Mitophagy, the selective removal of damaged mitochondria, is thought to be critical to maintain neuronal homeostasis. Mutations of proteins in the pathway cause neurodegenerative diseases, suggesting defective mitochondrial turnover contributes to neurodegeneration. In primary rat hippocampal neuron...
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| Pubblicato in: | eLife |
|---|---|
| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6959996/ https://ncbi.nlm.nih.gov/pubmed/31934852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50260 |
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