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Lysosomal degradation of depolarized mitochondria is rate-limiting in OPTN-dependent neuronal mitophagy

Damaged mitochondria are selectively removed from the cell in a process termed mitophagy. This mitochondrial quality control mechanism is important for neuronal homeostasis, and mutations in pathway components are causative for Parkinson disease and amyotrophic lateral sclerosis (ALS). Here, we disc...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Evans, Chantell S., Holzbaur, Erika L.F.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144876/
https://ncbi.nlm.nih.gov/pubmed/32131674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2020.1734330
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