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Lysosomal degradation of depolarized mitochondria is rate-limiting in OPTN-dependent neuronal mitophagy

Damaged mitochondria are selectively removed from the cell in a process termed mitophagy. This mitochondrial quality control mechanism is important for neuronal homeostasis, and mutations in pathway components are causative for Parkinson disease and amyotrophic lateral sclerosis (ALS). Here, we disc...

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Détails bibliographiques
Publié dans:Autophagy
Auteurs principaux: Evans, Chantell S., Holzbaur, Erika L.F.
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144876/
https://ncbi.nlm.nih.gov/pubmed/32131674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2020.1734330
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