Temporal dynamics of PARK2/parkin and OPTN/optineurin recruitment during the mitophagy of damaged mitochondria

Damaged mitochondria are selectively degraded via autophagy in a regulated pathway known as mitophagy. Parkinson disease-linked proteins PINK1 (PTEN induced putative kinase 1) and PARK2 (parkin RBR E3 ubiquitin protein ligase) are recruited to the outer mitochondrial membrane upon mitochondrial dama...

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Bibliographic Details
Published in:Autophagy
Main Authors: Wong, Yvette C, Holzbaur, Erika L F
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
Subjects:
Autophagic Puncta
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502688/
https://ncbi.nlm.nih.gov/pubmed/25801386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1009792
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