Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammatory responses downstream of TNFR1 and other receptors, and has been implicated in the pathogenesis of inflammatory and degenerative diseases. RIPK1 kinase activity induces apoptosis and necroptosis, however the mechanism...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Laurien, Lucie, Nagata, Masahiro, Schünke, Hannah, Delanghe, Tom, Wiederstein, Janica L., Kumari, Snehlata, Schwarzer, Robin, Corona, Teresa, Krüger, Marcus, Bertrand, Mathieu J. M., Kondylis, Vangelis, Pasparakis, Manolis
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7142081/
https://ncbi.nlm.nih.gov/pubmed/32269263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15466-8
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