Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammatory responses downstream of TNFR1 and other receptors, and has been implicated in the pathogenesis of inflammatory and degenerative diseases. RIPK1 kinase activity induces apoptosis and necroptosis, however the mechanism...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Laurien, Lucie, Nagata, Masahiro, Schünke, Hannah, Delanghe, Tom, Wiederstein, Janica L., Kumari, Snehlata, Schwarzer, Robin, Corona, Teresa, Krüger, Marcus, Bertrand, Mathieu J. M., Kondylis, Vangelis, Pasparakis, Manolis
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7142081/
https://ncbi.nlm.nih.gov/pubmed/32269263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15466-8
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