Hepatocyte IKK2 Protects Mdr2(−/−) Mice from Chronic Liver Failure

Mice lacking the Abc4 protein encoded by the multidrug resistance-2 gene (Mdr2 (−/−)) develop chronic periductular inflammation and cholestatic liver disease resulting in the development of hepatocellular carcinoma (HCC). Inhibition of NF-κB by expression of an IκBα super-repressor (IκBαSR) transgen...

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Bibliografische gegevens
Hoofdauteurs: Ehlken, Hanno, Kondylis, Vangelis, Heinrichsdorff, Jan, Ochoa-Callejero, Laura, Roskams, Tania, Pasparakis, Manolis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2011
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195080/
https://ncbi.nlm.nih.gov/pubmed/22022477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025942
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