NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis

IκB kinase/nuclear factor κB (IKK/NF-κB) signaling exhibits important yet opposing functions in hepatocarcinogenesis. Mice lacking NEMO in liver parenchymal cells (LPC) spontaneously develop steatohepatitis and hepatocellular carcinoma (HCC) suggesting that NF-κB prevents liver disease and cancer. H...

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Vydáno v:Cancer Cell
Hlavní autoři: Kondylis, Vangelis, Polykratis, Apostolos, Ehlken, Hanno, Ochoa-Callejero, Laura, Straub, Beate Katharina, Krishna-Subramanian, Santosh, Van, Trieu-My, Curth, Harald-Morten, Heise, Nicole, Weih, Falk, Klein, Ulf, Schirmacher, Peter, Kelliher, Michelle, Pasparakis, Manolis
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4644221/
https://ncbi.nlm.nih.gov/pubmed/26555174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.10.001
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