NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of inflammatory bowel diseases (IBD). IEC-specific ablation of nuclear factor κB (NF-κB) essential modulator (NEMO) caused Paneth cell apoptosis and impaired antim...

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Bibliographic Details
Published in:Immunity
Main Authors: Vlantis, Katerina, Wullaert, Andy, Polykratis, Apostolos, Kondylis, Vangelis, Dannappel, Marius, Schwarzer, Robin, Welz, Patrick, Corona, Teresa, Walczak, Henning, Weih, Falk, Klein, Ulf, Kelliher, Michelle, Pasparakis, Manolis
Format: Artigo
Language:Inglês
Published: Cell Press 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4803910/
https://ncbi.nlm.nih.gov/pubmed/26982364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.02.020
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