Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury

The inhibitor of NF-κB (I-κB) kinase (IKK) complex consists of 3 subunits, IKK1, IKK2, and NF-κB essential modulator (NEMO), and is involved in the activation of NF-κB by various stimuli. IKK2 or NEMO constitutive knockout mice die during embryogenesis as a result of massive hepatic apoptosis. There...

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Main Authors: Luedde, Tom, Assmus, Ulrike, Wüstefeld, Torsten, Meyer zu Vilsendorf, Andreas, Roskams, Tania, Schmidt-Supprian, Mark, Rajewsky, Klaus, Brenner, David A., Manns, Michael P., Pasparakis, Manolis, Trautwein, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1064982/
https://ncbi.nlm.nih.gov/pubmed/15776110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200523493
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