Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice

Many cancers display increased NF-κB activity, and NF-κB inhibition is known to diminish tumor development in multiple mouse models, supporting an important role of NF-κB in carcinogenesis. NF-κB activation in premalignant or cancer cells is believed to promote tumor development mainly by protecting...

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Huvudupphovsmän: Vlantis, Katerina, Wullaert, Andy, Sasaki, Yoshiteru, Schmidt-Supprian, Marc, Rajewsky, Klaus, Roskams, Tania, Pasparakis, Manolis
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2011
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223831/
https://ncbi.nlm.nih.gov/pubmed/21701067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45349
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