BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells

B cell activating factor (BAFF) signals through BAFF-R to promote mature B cell survival. Recent analyses of BAFF-induced signaling revealed direct association between augmented B cell metabolic fitness and activation of Akt, one of the key regulators of cell survival. The strongest and most reprodu...

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Main Authors: Otipoby, Kevin L., Sasaki, Yoshiteru, Schmidt-Supprian, Marc, Patke, Alina, Gareus, Ralph, Pasparakis, Manolis, Tarakhovsky, Alexander, Rajewsky, Klaus
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2008
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527929/
https://ncbi.nlm.nih.gov/pubmed/18713867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805460105
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