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NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells

BAFF-R-dependent activation of the alternative NF-κB pathway plays an essential role in mature B cell survival. Mutations leading to overexpression of NIK and deletion of the TRAF3 gene are implicated in human multiple myeloma. We show that overexpression of NIK in mouse B lymphocytes amplifies alte...

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Detalhes bibliográficos
Main Authors: Sasaki, Yoshiteru, Calado, Dinis P., Derudder, Emmanuel, Zhang, Baochun, Shimizu, Yuri, Mackay, Fabienne, Nishikawa, Shin-ichi, Rajewsky, Klaus, Schmidt-Supprian, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504772/
https://ncbi.nlm.nih.gov/pubmed/18663224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805186105
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