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Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice
Many cancers display increased NF-κB activity, and NF-κB inhibition is known to diminish tumor development in multiple mouse models, supporting an important role of NF-κB in carcinogenesis. NF-κB activation in premalignant or cancer cells is believed to promote tumor development mainly by protecting...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3223831/ https://ncbi.nlm.nih.gov/pubmed/21701067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45349 |
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