C3a receptor blockade protects podocytes from injury in diabetic nephropathy

Renal activation of the complement system has been described in patients with diabetic nephropathy (DN), although its pathological relevance is still ill-defined. Here, we studied whether glomerular C3a, generated by uncontrolled complement activation, promotes podocyte damage, leading to proteinuri...

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Vydáno v:JCI Insight
Hlavní autoři: Morigi, Marina, Perico, Luca, Corna, Daniela, Locatelli, Monica, Cassis, Paola, Carminati, Claudia Elisa, Bolognini, Silvia, Zoja, Carlamaria, Remuzzi, Giuseppe, Benigni, Ariela, Buelli, Simona
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141402/
https://ncbi.nlm.nih.gov/pubmed/32161193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131849
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