C3a receptor blockade protects podocytes from injury in diabetic nephropathy

Renal activation of the complement system has been described in patients with diabetic nephropathy (DN), although its pathological relevance is still ill-defined. Here, we studied whether glomerular C3a, generated by uncontrolled complement activation, promotes podocyte damage, leading to proteinuri...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Morigi, Marina, Perico, Luca, Corna, Daniela, Locatelli, Monica, Cassis, Paola, Carminati, Claudia Elisa, Bolognini, Silvia, Zoja, Carlamaria, Remuzzi, Giuseppe, Benigni, Ariela, Buelli, Simona
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141402/
https://ncbi.nlm.nih.gov/pubmed/32161193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131849
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